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"Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA〔3,4-methylenedioxy-N-methylamphetamine (MDMA) is the chemical name for the psychotropic drug commonly known as "ecstasy".〕 ("ecstasy")", was a paper by Dr. George Ricaurte which was published in the leading journal ''Science'', and later retracted. The reason was that instead of using MDMA, methamphetamine had been used in the test.〔 The retraction of the paper led to questions over its publication. It has also been asserted that this questions the peer review process. Many have also argued that the failings in the paper (use of materials other than those specified) could not have been caught by peer review; and that the scientific process did work successfully in the end, in that the article was ultimately retracted. The paper was published in the 27 September 2002 issue of ''Science'' (volume 297, pages 2260-3).〔 The article had been submitted to ''Science'' on 29 May 2002 and was accepted for publication on 14 August 2002. Neither the time required for peer review nor the time between acceptance for publication and actual date of publication were unusual. ==Original publication== The Ricaurte article was published in the middle of a group of 16 "reports" and not given special prominence in the "Highlights of research in this issue" section of the 27 September 2002 issue of ''Science''.〔(27 September 2002 issue ), ''Science'' 297 (5590)〕 The short editorial commentary on the article was called "More Dangers from Designer Drugs" and drew the reader's attention to previously published research indicating that "ecstasy" use alters serotoninergic synaptic transmission. ''Science'' also commented that by linking "ecstasy" to dopaminergic neurotoxicity in monkeys, the Ricaurte article suggested that recreational users of "ecstasy" might be putting themselves at risk for developing neuropsychiatric disorders (such as Parkinson's disease) that are related to dopamine dysfunction. The ''Science'' section called "News of the Week" in the 27 September 2002 issue had an article by reporter Constance Holden called, "Drug Find Could Give Ravers the Jitters" (on pages 2185-2187). This news coverage did give some special prominence to the Ricaurte article. The Holden commentary stressed that the Ricaurte article was part of an active scientific controversy about the ability of "ecstasy" to cause permanent brain damage in human recreational drug users. This news article included a section with speculation from Ricaurte trying to justify why other researchers fail to observe ecstasy-induced dopaminergic neurotoxicity. Jon Cole of the University of Liverpool explained that the results on dopaminergic neurotoxicity in the Ricaurte article were a big surprise and was quoted as saying, "The entire human literature relies on the notion that MDMA is a selective serotonergic neurotoxin." 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Retracted article on dopaminergic neurotoxicity of MDMA」の詳細全文を読む スポンサード リンク
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